Deschloroclozapine is an effective, high affinity, selective, metabolically stable agonist based on muscarinic DREADDs. The Ki binding values of Deschloroclozapine to DREADD receptor subtypes hM3Dq and hM4Di were 6.3 and 4.2 nM, respectively.
| Molecular Weight | 292.38 |
| Formula | C18H20N4 |
| CAS Number | 1977-07-7 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | Powder -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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