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Deltorphin 2 TFA

Cat. No. M14028
Deltorphin 2 TFA Structure
Synonym:

[D-Ala2]-Deltorphin II TFA

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Biological Activity

Deltorphin 2 TFA is a selective peptide agonist for the δ opioid receptor.

Chemical Information
Molecular Weight 896.91
Solubility (25°C) DMSO 50 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Małgorzata Ciszewska, et al. Cyclic enkephalin-deltorphin hybrids containing a carbonyl bridge: structure and opioid activity

[2] T Toyo'oka, et al. R(-)-4-(3-Isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, a fluorescent chiral tagging reagent: sensitive resolution of chiral amines and amino acids by reversed-phase liquid chromatography

[3] T Toyo'oka, et al. Separation of 17 DL-amino acids and chiral sequential analysis of peptides by reversed-phase liquid chromatography after labeling with R(-)-4- (3-isothiocyanatopyrrolidin-1-yl)-7-(N, N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole

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Keywords: Deltorphin 2 TFA, [D-Ala2]-Deltorphin II TFA supplier, Opioid Receptor, inhibitors, activators


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