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Delavirdine mesylate

Cat. No. M2173

Delavirdine mesylate Structure

Synonym: U-90152

Size Price Availability Quantity
100mg USD 180 In stock
500mg USD 460 In stock
1g USD 660 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Delavirdine mesylate (U-90152) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1. Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases with IC50 values of 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ. U-90152 (Delavirdine mesylate) blocked the replication in peripheral blood lymphocytes of 25 primary HIV-1 isolates with a mean 50% effective dose of 0.066 +/- 0.137 microM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 552.67
Formula C22H28N6O3S.CH3SO3H
CAS Number 147221-93-0
Purity >99%
Solubility DMSO
Storage at -20°C
References

U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication.
Dueweke TJ, et al. Antimicrob Agents Chemother. 1993 May;37(5):1127-31. PMID: 7685995.

In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha.
Pagano PJ, et al. J Infect Dis. 1995 Jan;171(1):61-7. PMID: 7528253.

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Abmole Inhibitor Catalog 2017




Keywords: Delavirdine mesylate, U-90152 supplier, HIV Protease, inhibitors

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