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Dehydrocostus-Lactone

Cat. No. M4476
Dehydrocostus-Lactone Structure
Synonym:

(-)-Dehydrocostus lactone; Epiligulyl oxide

Size Price Availability Quantity
20mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Dehydrocostus-Lactone (DHE) is a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter.

Chemical Information
Molecular Weight 230.3
Formula C15H18O2
CAS Number 477-43-0
Solubility (25°C) DMSO 40 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wenlong Wu, et al. Dynamics of germination stimulants dehydrocostus lactone and costunolide in the root exudates and extracts of sunflower

[2] Ya-Xian Wu, et al. Dehydrocostus Lactone Attenuates Methicillin-Resistant Staphylococcus aureus-Induced Inflammation and Acute Lung Injury via Modulating Macrophage Polarization

[3] Hong Cai, et al. Effect of Dehydrocostus Lactone on Proliferation of K562 Cells and Its Mechanism

[4] Yunjuan Nie, et al. Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt

[5] Zhaoning Li, et al. Dehydrocostus lactone (DHC) suppresses estrogen deficiency-induced osteoporosis

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Keywords: Dehydrocostus-Lactone, (-)-Dehydrocostus lactone; Epiligulyl oxide supplier, IκB/IKK, inhibitors, activators


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