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Defactinib

Cat. No. M4872
Defactinib Structure
Synonym:

VS-6063, PF-04554878

Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 150 In stock
10mg USD 180 In stock
50mg USD 350 In stock
50mg USD 400 In stock
100mg USD 570 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

The combination of VS-6063 and paclitaxel synergistically decreases proliferation and increases apoptosis in SKOV3ip1, SKOV3-TR, HeyA8 and HeyA8-MDR cells. In both PTX-sensitive and PTX-resistant models, VS-6063 (50 mg/kg p.o.) enhances tumor growth inhibition by paclitaxel.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 510.49
Formula C20H21F3N8O3S
CAS Number 1073154-85-4
Purity >99%
Solubility DMSO 5 mg/mL
Water <1 mg/mL
Storage at -20°C
References

Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer.
Kang Y, et.al. J Natl Cancer Inst. 2013 Oct 2;105(19). PMID: 24062525.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Defactinib, VS-6063, PF-04554878 supplier, FAK, inhibitors

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