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Decernotinib

Cat. No. M4980
Decernotinib Structure
Synonym:

VX-509; VRT-831509

Size Price Availability Quantity
10mM*1mL In DMSO USD 120 In stock
2mg USD 70 In stock
5mg USD 100 In stock
10mg USD 180 In stock
50mg USD 540 In stock
100mg USD 900 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

VX-509 potently inhibits JAK3 in enzyme assays (Ki =2.5 nM + 0.7 nM) and cellular assays dependent on JAK3 activity (IC50 range, 50-170 nM), with limited or no measurable potency against other JAK isotypes or non-JAK kinases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 392.38
Formula C18H19F3N6O
CAS Number 944842-54-0
Purity >98%
Solubility DMSO
Storage at -20°C
References

VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease.
Mahajan S,et.al. J Pharmacol Exp Ther 2015 May;405-14. PMID: 25762693.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Decernotinib, VX-509; VRT-831509 supplier, JAK, inhibitors

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