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DCC2701

Cat. No. M4966

DCC2701 Structure

Synonym: Altiratinib

Size Price Availability Quantity
2mg USD 240 In stock
5mg USD 360 In stock
10mg USD 540 In stock
50mg USD 1480 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 510.46
Formula C26H21F3N4O4
CAS Number 1345847-93-9
Purity >99%
Solubility DMSO: 33mg/mL
Storage at -20°C
References

Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment.
Kwon Y,et.al. Oncogene 2015 Jan 8;144-53. PMID: 24362531.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: DCC2701, Altiratinib supplier, c-Met, inhibitors

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