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Dasatinib Monohydrate

Cat. No. M5553
Dasatinib Monohydrate Structure
Synonym:

BMS-354825 Monohydrate

Size Price Availability Quantity
50mg USD 80 In stock
200mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 506.02
Formula C22H28ClN7O3S
CAS Number 863127-77-9
Purity >99%
Solubility 21 mg/mL warmed in DMSO
Storage at -20°C
References

Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate phases.
Roy S, et al. Cryst Growth Des. 2012 Apr 4;12(4):2122-2126. PMID: 23472049.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dasatinib Monohydrate, BMS-354825 Monohydrate supplier, Src-bcr-Abl, inhibitors

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