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Dasatinib Monohydrate

Cat. No. M5553
Dasatinib Monohydrate Structure
Synonym:

BMS-354825 Monohydrate

Size Price Availability Quantity
50mg USD 80  USD80 In stock
200mg USD 160  USD160 In stock
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Quality Control & Documentation
Biological Activity

Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.

Chemical Information
Molecular Weight 506.02
Formula C22H28ClN7O3S
CAS Number 863127-77-9
Solubility (25°C) 21 mg/mL warmed in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Roy S, et al. Cryst Growth Des. Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate phases.

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Keywords: Dasatinib Monohydrate, BMS-354825 Monohydrate supplier, Src-bcr-Abl, inhibitors, activators


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