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Dasatinib HCl

Cat. No. M5552
Dasatinib HCl Structure
Synonym:

BMS 354825 hydrochloride

Size Price Availability Quantity
5mg USD 40  USD40 In stock
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Quality Control & Documentation
Biological Activity

Dasatinib(BMS-354825) hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of <1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.

Chemical Information
Molecular Weight 524.47
Formula C22H27Cl2N7O2S
CAS Number 854001-07-3
Solubility (25°C) 15 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cortes JE, et al. Am J Hematol. The impact of dasatinib on pregnancy outcomes.

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Keywords: Dasatinib HCl, BMS 354825 hydrochloride supplier, Src-bcr-Abl, inhibitors, activators


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