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Dasatinib HCl

Cat. No. M5552
Dasatinib HCl Structure
Synonym:

BMS 354825 hydrochloride

Size Price Availability Quantity
100mg USD 60 In stock
500mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dasatinib(BMS-354825) hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of <1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 524.47
Formula C22H27Cl2N7O2S
CAS Number 854001-07-3
Purity >98%
Solubility 15 mg/mL in DMSO
Storage at -20°C
References

The impact of dasatinib on pregnancy outcomes.
Cortes JE, et al. Am J Hematol. 2015 Dec;90(12):1111-5. PMID: 26348106.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dasatinib HCl, BMS 354825 hydrochloride supplier, Src-bcr-Abl, inhibitors

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