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Darunavir Ethanolate

Cat. No. M3568
Darunavir Ethanolate Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 59  USD59 In stock
5mg USD 47  USD47 In stock
10mg USD 83  USD83 In stock
50mg USD 255  USD255 In stock
100mg USD 447  USD447 In stock
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Quality Control
Biological Activity

Darunavir Ethanolate is an inhibitor of HIV protease. Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutations to PIs.

Customer Product Validations & Biological Datas
Source AAPS PharmSciTech (2017). Figure 7.Darunavir Ethanolate
Method LC-MS method
Cell Lines Wistar rats
Concentrations 40 mg/kg
Incubation Time 0.5, 1, 2, 4, 8, and 24 h
Results The plasma concentration of darunavir in rats after oral administration of SLNs and peptide-grafted SLNs showed no significant difference (P > 0.5).
Source AAPS PharmSciTech (2017). Figure 4.Darunavir Ethanolate
Method Identification of Internalization Pathway
Cell Lines Caco-2 cell line
Incubation Time 0.5, 1, 2, 3, and 4 h
Results The relative uptake efficiency of darunavir in presence of endocytic inhibitors is graphically depicted in Fig. 4.
Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 593.73
Formula C27H37N3O7S.C2H5OH
CAS Number 635728-49-3
Purity >99%
Solubility DMSO ≥ 50 mg/mL
Storage at -20°C

[1] Nguyen DN, et al. Int J Pharm. The fate of ritonavir in the presence of darunavir.

[2] Stappaerts J, et al. Xenobiotica. Hepatobiliary and intestinal elimination of darunavir in an integrated preclinical rat model.

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Keywords: Darunavir Ethanolate, TMC114 supplier, HIV Protease, inhibitors

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