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Darunavir Ethanolate

Cat. No. M3568

Darunavir Ethanolate Structure

Synonym: TMC114

Size Price Availability Quantity
5mg USD 90 In stock
10mg USD 145 In stock
50mg USD 510 In stock
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Quality Control
Biological Activity

Darunavir Ethanolate (Prezista) is an inhibitor of HIV protease. Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutations to PIs.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 593.73
Formula C27H37N3O7S.C2H5OH
CAS Number 635728-49-3
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




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