Free shipping on all orders over $ 500

Darunavir Ethanolate

Cat. No. M3568
Darunavir Ethanolate Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 60 In stock
10mg USD 100 In stock
50mg USD 300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Darunavir Ethanolate (Prezista) is an inhibitor of HIV protease. Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutations to PIs.

Customer Product Validations & Biological Datas
Source AAPS PharmSciTech (2017). Figure 7.Darunavir Ethanolate
Method LC-MS method
Cell Lines Wistar rats
Concentrations 40 mg/kg
Incubation Time 0.5, 1, 2, 4, 8, and 24 h
Results The plasma concentration of darunavir in rats after oral administration of SLNs and peptide-grafted SLNs showed no significant difference (P > 0.5).
Source AAPS PharmSciTech (2017). Figure 4.Darunavir Ethanolate
Method Identification of Internalization Pathway
Cell Lines Caco-2 cell line
Incubation Time 0.5, 1, 2, 3, and 4 h
Results The relative uptake efficiency of darunavir in presence of endocytic inhibitors is graphically depicted in Fig. 4.
Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 593.73
Formula C27H37N3O7S.C2H5OH
CAS Number 635728-49-3
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C

The fate of ritonavir in the presence of darunavir.
Nguyen DN, et al. Int J Pharm. 2014 Nov 20;475(1-2):214-26. PMID: 25180992.

Hepatobiliary and intestinal elimination of darunavir in an integrated preclinical rat model.
Stappaerts J, et al. Xenobiotica. 2014 Jun;44(6):489-97. PMID: 24274355.

Related HIV Protease Products

BMS-626529 is a potent HIV-1 attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells.


Darunavir is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

Saquinavir Mesylate

Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.


Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.


Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

Abmole Inhibitor Catalog 2017

Keywords: Darunavir Ethanolate, TMC114 supplier, HIV Protease, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.