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Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Cat. No. M5551
Dapagliflozin ((2S)-1,2-propanediol, hydrate) Structure
Synonym:

BMS-512148 (2S)-1,2-propanediol, hydrate

Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 120 In stock
50mg USD 300 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dapagliflozin(BMS512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) is in development for the treatment of type 2 diabetes mellitus (T2DM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 502.98
Formula C24H35ClO9
CAS Number 960404-48-2
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

SGLT2 inhibitors: a new emerging therapeutic class in the treatment of type 2 diabetes mellitus.
Ghosh RK, et al. J Clin Pharmacol. 2012 Apr;52(4):457-63. PMID: 21543663.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dapagliflozin ((2S)-1,2-propanediol, hydrate), BMS-512148 (2S)-1,2-propanediol, hydrate supplier, SGLT, inhibitors

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