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DAMGO

Cat. No. M9615
DAMGO Structure
Synonym:

RX783006; Dagol

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 155  USD155 In stock
25mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents, Kd value is 3.46 nM for native μ-OPR. DAMGO abolishes the neuroprotective effect of CXCL12 in N-methyl-d-aspartate (NMDA) neurotoxicity studies.

Product Citations
Chemical Information
Molecular Weight 513.59
Formula C26H35N5O6
CAS Number 78123-71-4
Solubility (25°C) DMSO ≥ 21 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jeegar P Patel, et al. J Neurovirol. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO

[2] T Onogi, et al. FEBS Lett. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops

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Keywords: DAMGO, RX783006; Dagol supplier, Opioid Receptor, inhibitors, activators


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