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Dacarbazine

Cat. No. M2216

Dacarbazine Structure
Size Price Availability Quantity
200mg USD 75 In stock
500mg USD 120 In stock
1g USD 200 In stock
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Biological Activity

Dacarbazine (also known as DIC or Imidazole Carboxamide) is a triazine antineoplastic agent. Dacarbazine is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group to its DNA. Dacarbazine has significant activity against melanomas. Dacarbazine appears to exert cytotoxic effects by acting as an alkylating agent, by inhibiting DNA synthesis as a purine analog, and by inducing apoptosis. Dacarbazine is used as an antineoplastic in the treatment of malignant melanoma and sarcomas.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 182.18
Formula C6H10N6O
CAS Number 4342-03-4
Purity >99%
Solubility Water
Ethanol
Storage at -20°C
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Keywords: Dacarbazine supplier, DNA/RNA Synthesis, inhibitors

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