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CZC24832

Cat. No. M2609
CZC24832 Structure
Size Price Availability Quantity
5mg USD 90 In stock
10mg USD 135 In stock
50mg USD 500 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.

Customer Product Validations & Biological Datas
Source Cell Rep (2016). Figure 3. CZC24832
Method western blot
Cell Lines neutrophils
Concentrations 10 μM
Incubation Time 24 h
Results Use of isoform-specific inhibitors, including the PI3Kg-selective AS252424 and CZC24832, suggested that this was due to PI3Kg
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 364.4
Formula C15H17FN6O2S
CAS Number 1159824-67-5
Purity >98%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CZC24832 supplier, PI3K, inhibitors

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