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Cysteamine hydrochloride

Cat. No. M2548
Cysteamine hydrochloride Structure
Synonym:

β-MEA Hydrochloride; β-Mercaptoethylamine Hydrochloride; 2-Aminoethanethiol Hydrochloride

Size Price Availability Quantity
10mM*1mL in DMSO USD 40  USD40 In stock
1g USD 40  USD40 In stock
5g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Cysteamine HCl, the hydrochloride form of Cysteamine, is also a transglutaminase 2 (TGM2) inhibitor, which can be used to induce gastrointestinal disorders in a mouse model as well as a duodenal ulcer model. In addition, Cysteamine HCl has the ability to modulate the activity of dopamine neurons in the striatum of awake, freely moving rats by inhibiting the increased dopamine release from amphetamine, and has antioxidant activity.

Chemical Information
Molecular Weight 113.61
Formula C2H7NS.HCl
CAS Number 156-57-0
Solubility (25°C) DMSO ≥ 23 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Carla Atallah, et al. Effect of cysteamine hydrochloride-loaded liposomes on skin depigmenting and penetration

[2] Najmeh Ahramiyanpour, et al. Efficacy of topical cysteamine hydrochloride in treating melasma: a systematic review

[3] Hong Liang, et al. Long-term follow-up of cystinosis patients treated with 0.55% cysteamine hydrochloride

[4] Thomas M Jeitner, et al. Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo

[5] Martine Besouw, et al. Cysteamine: an old drug with new potential

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Keywords: Cysteamine hydrochloride, β-MEA Hydrochloride; β-Mercaptoethylamine Hydrochloride; 2-Aminoethanethiol Hydrochloride supplier, Animal Modeling, inhibitors, activators


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