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Cyproheptadine HCl

Cat. No. M5542
Cyproheptadine HCl Structure
Size Price Availability Quantity
50mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 323.86
Formula C21H22ClN
CAS Number 969-33-5
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

FT-IR and FT-Raman spectra, molecular structure and first-order molecular hyperpolarizabilities of a potential antihistaminic drug, cyproheptadine HCl.
Sagdinc SG, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 5;134:350-60. PMID: 25022508.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cyproheptadine HCl supplier, 5-HT Receptor, inhibitors

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