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Cyclophosphamide

Cat. No. M3746

Cyclophosphamide Structure
Size Price Availability Quantity
50mg USD 60 In stock
500mg USD 280 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Cyclophosphamide inhibits the AChE reversibly with an IC50 of 511 microM. The Michaelis-Menten constant (Km) was 132 microM for AChE in the control system; a value increased by 78% in the CP treated system. The Vmax was 73.8 mumol/h/mg protein for the control system. Cyclophosphamide is used to treat cancers and autoimmune disorders. Cyclophosphamide belongs to a group of drugs called alkylating agents. It works by sticking to one of the cancer cell's DNA strands. DNA is the genetic code that is in the heart of all animal and plant cells. It controls everything the cell does.The cell cannot then divide into 2 new cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 261.09
Formula C7H15Cl2N2O2P
CAS Number 50-18-0
Purity >99%
Solubility DMSO 52mg/mL
Water 43 mg/mL
Ethanol 52 mg/mL
Storage at -20°C
References

Inhibition of human acetylcholinesterase by cyclophosphamide.
al-Jafari AA, et al. Toxicology. 1995 Jan 19;96(1):1-6. PMID: 7863507.

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