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Cycloastragenol (Cyclogalegigenin)

Cat. No. M4048
Cycloastragenol (Cyclogalegigenin)  Structure
Synonym:

Cyclogalegigenin

Size Price Availability Quantity
20mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Cycloastragenol (Cyclogalegigenin) is an isoprene found in Astragalus galegiformis. Cyclogalegenin is an isomer of Cycloastragenol.

Chemical Information
Molecular Weight 490.71
Formula C30H50O5
CAS Number 84605-18-5
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Muhammad Ikram, et al. Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions

[2] Jiahuan Wu, et al. Cycloastragenol protects against glucocorticoid-induced osteogenic differentiation inhibition by activating telomerase

[3] Man Li, et al. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia

[4] Chen Chen, et al. Anti-aging derivatives of cycloastragenol produced by biotransformation

[5] Yongjie Yu, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases

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Keywords: Cycloastragenol (Cyclogalegigenin) , Cyclogalegigenin supplier, inhibitors, activators


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