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Cucurbitacin I

Cat. No. M10697
Cucurbitacin I Structure
Synonym:

Elatericin B; JSI-124; NSC-521777

Size Price Availability Quantity
5mg USD 440  USD440 In stock
10mg USD 660  USD660 In stock
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Quality Control & Documentation
Biological Activity

Cucurbitacin I is a naturally selective inhibitor of JAK2/STAT3 and has potent antitumor activity.

Chemical Information
Molecular Weight 514.65
Formula C30H42O7
CAS Number 2222-07-3
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bothaina Al-Harbi, et al. Mol Carcinog. Cucurbitacin I (JSI-124)-dependent inhibition of STAT3 permanently suppresses the pro-carcinogenic effects of active breast cancer-associated fibroblasts

[2] Isabella J Brouwer, et al. Biochem Biophys Rep. Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells

[3] Ruli Li, et al. Mol Med Rep. Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis

[4] Prasad Dandawate, et al. Sci Rep. Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway

[5] Yinyun Ni, et al. J Cell Biochem. Cucurbitacin I induces pro-death autophagy in A549 cells via the ERK-mTOR-STAT3 signaling pathway

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Keywords: Cucurbitacin I, Elatericin B; JSI-124; NSC-521777 supplier, STAT, inhibitors, activators


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