CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
|Source||PLoS One (2011). Figure 3. CRT0044876|
|Cell Lines||The U251-MG glioblastoma multiforme (GBM) cell line|
|Incubation Time||2 h|
|Results||Nonetheless, in our cell system, CRT could inhibit APE1 protein at high concentrations (200 μM), as opposed to the inhibition we observed by lucanthone at 50 μM.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 30 mg/mL|
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