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CPI-169

Cat. No. M11243
CPI-169 Structure
Synonym:

CPI 169 R-enantiomer

Size Price Availability Quantity
5mg USD 290  USD290 In stock
10mg USD 410  USD410 In stock
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Quality Control & Documentation
Biological Activity

Cpi-169 (CPI 169 R-Enantiomer) is a novel and effective EZH2 inhibitor, capable of inhibiting the activity of EZH2 WT, EZH2 Y641N and EZH1 with IC50 value of 0.24 nM, respectively. 0.51 nM and 6.1 nM.

Chemical Information
Molecular Weight 528.66
Formula C27H36N4O5S
CAS Number 1802175-07-0
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhengnan Shen, et al. bioRxiv. Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

[2] Adolphe Nfotabong-Atheull, et al. J Ethnobiol Ethnomed. Assessing forest products usage and local residents' perception of environmental changes in peri-urban and rural mangroves of Cameroon, Central Africa

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  Catalog
Abmole Inhibitor Catalog




Keywords: CPI-169, CPI 169 R-enantiomer supplier, Histone Methyltransferase, inhibitors, activators


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