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Coumarin 2

Cat. No. M11536
Coumarin 2 Structure
Synonym:

7-(Ethylamino)-4,6-dimethylcoumarin

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Quality Control & Documentation
Biological Activity

7-(ethylamino)-4,6-dimethylchromen-2-one

Chemical Information
Molecular Weight 217.26
Formula C13H15NO2
CAS Number 26078-25-1
Solubility (25°C) N/A
Storage RT
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Harish C Upadhyay. Curr Top Med Chem. Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance

[2] Bhavani Shankar Chinta, et al. Org Lett. Coumarin (5,6-Benzo-2-pyrone) Trapping of an HDDA-Benzyne

[3] Nadeem Ahmed, et al. J Fluoresc. Coumarin-Based Reversible Fluorescent Probe for Selective Detection of Cu 2+ in Living Cells

[4] Fernando de Carvalho da Silva, et al. Curr Top Med Chem. Editorial: Biological Profiles of Coumarin Scaffold - Part 2

[5] J L Mohler, et al. J Cancer Res Clin Oncol. Coumarin (1,2-benzopyrone) for the treatment of prostatic carcinoma

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Keywords: Coumarin 2, 7-(Ethylamino)-4,6-dimethylcoumarin supplier, inhibitors, activators


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