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Cotadutide acetate

Cat. No. M9749
Cotadutide acetate Structure
Synonym:

MEDI0382 acetate

Size Price Availability
5mg USD 810  USD900 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >96%
  • COA
  • MSDS
Biological Activity

Cotadutide acetate is a potent peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor, with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate (MEDI0382 acetate) shows EC50 values of 6.9 and 10.2 pM as measured by cAMP generation in CHO cells over‐expressing human recombinant GLP‐1 or glucagon receptors in the presence of 0.1% BSA, which are within 10‐fold of the native ligands.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3788.14
Formula C169H256N42O57
CAS Number
Purity >96%
Solubility DMSO 2 mg/mL
Storage -20°C, dry, sealed
References

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates
S J Henderson, et al. Diabetes Obes Metab. 2016 Dec;18(12):1176-1190. PMID: 27377054.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cotadutide acetate, MEDI0382 acetate supplier, Glucagon Receptor, inhibitors

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