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ACTH (1-39) TFA

Cat. No. M10392
ACTH (1-39) TFA Structure
Synonym:

Adrenocorticotropic hormone; Corticotropin

Size Price Availability Quantity
5mg USD 160  USD160 In stock
10mg USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

ACTH (1-39) TFA is a polypeptide hormone extracted from the anterior lobe of the pituitary gland of mammals, acts on the adrenal cortex, and has the effect of promoting the proliferation of adrenal cortex tissue and the production and secretion of corticosteroids. Corticotropin is easily soluble in water and ethanol. It is more stable in weak acid, and easily inactivated in strong acid or alkali.

Chemical Information
CAS Number 9002-60-2 (free base)
Solubility (25°C) Water ≥ 1 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Christen F Kutz, et al. Neurodegener Dis Manag. Repository corticotropin injection in multiple sclerosis: an update

[2] P BARFOED. Nord Med. [Corticotropin in arteritis temporalis]

[3] M Schneshfer, et al. Surv Immunol Res. Corticotropin in human plasma. General considerations

[4] F Garmendia. Rev Soc Peru Endocrinol. [Review of corticotropin metabolism]

[5] H Bories. Infirm Fr. [Corticotropin (A.C.T.H.)]

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Keywords: ACTH (1-39) TFA, Adrenocorticotropic hormone; Corticotropin supplier, Androgen Receptor, inhibitors, activators


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