ACTH (1-39) TFA is a polypeptide hormone extracted from the anterior lobe of the pituitary gland of mammals, acts on the adrenal cortex, and has the effect of promoting the proliferation of adrenal cortex tissue and the production and secretion of corticosteroids. Corticotropin is easily soluble in water and ethanol. It is more stable in weak acid, and easily inactivated in strong acid or alkali.
CAS Number | 9002-60-2 (free base) |
Solubility (25°C) | Water ≥ 1 mg/mL |
Storage | -20°C, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] P BARFOED. Nord Med. [Corticotropin in arteritis temporalis]
[3] M Schneshfer, et al. Surv Immunol Res. Corticotropin in human plasma. General considerations
[4] F Garmendia. Rev Soc Peru Endocrinol. [Review of corticotropin metabolism]
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(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH). |
Acetyl-ACTH (2-24) (human, bovine, rat)
Acetyl-ACTH (2-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
Acetyl-ACTH (3-24) (human, bovine, rat)
Acetyl-ACTH (3-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
Acetyl-ACTH (4-24) (human, bovine, rat)
Acetyl-ACTH (4-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
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