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Compstatin

Cat. No. M8983
Compstatin Structure
Synonym:

ICVVQDWGHHRCT

Size Price Availability
5mg USD 270 1-2 Weeks
25mg USD 890 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Compstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. Compstatin features a high selectivity for human and primate C3. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Juvenile baboons (P. anubis)
Formulation PBS
Dosages 17, 21, 34, 38.5, 50, 63.5 mg/kg
Administration by bolus injection, infusion, or both
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1550.77
Formula C66H99N23O17S2
CAS Number 206645-99-0
Purity >98%
Solubility Water ≥ 90 mg/mL
Storage at -20°C
References

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention.
Mastellos DC, et al. Eur J Clin Invest. 2015 Apr;45(4):423-40. PMID: 25678219.

Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons.
Soulika AM, et al. Clin Immunol. 2000 Sep;96(3):212-21. PMID: 10964539.

Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin.
Sahu A, et al. J Immunol. 2000 Sep 1;165(5):2491-9. PMID: 10946275.

Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts.
Fiane AE, et al. Xenotransplantation. 1999 Feb;6(1):52-65. PMID: 10355733.

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  Catalog
Abmole Inhibitor Catalog 2017




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