Colcemid (Demecolcine) is an effective mitotic inhibitor. Colcemid binds tubulin and blocks cells for metaphase karyotype analysis. Colcemid can induce apoptosis and can be used in tumor research.
Molecular Weight | 371.43 |
Formula | C21H25NO5 |
CAS Number | 477-30-5 |
Solubility (25°C) | DMSO ≥ 20 mg/mL |
Storage | 2-8°C |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Stefan Florian, et al. Methods Mol Biol. Anti-Microtubule Drugs
[3] T W SHEEHY, et al. AMA Arch Intern Med. Demecolcine (colcemid) toxicity
[5] C L Rieder, et al. J Cell Sci. Colcemid and the mitotic cycle
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