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Clomethiazole

Cat. No. M9188
Clomethiazole Structure
Size Price Availability Quantity
1g USD 65 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Clomethacazole is a thiol (vitamin B1)-related compound that acts as a thiazole derivative. Clomethiazole is a positive allosteric modulator at the barbiturate/picrotoxin site of the GABAA receptor. It acts as a sedative and hypnotic agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 161.64
Formula C6H8ClNS
CAS Number 533-45-9
Purity >98%
Solubility DMSO 10 mM
Storage 4°C, dry, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Clomethiazole supplier, inhibitors

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