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Clinafloxacin

Cat. No. M2526
Clinafloxacin Structure
Synonym:

CI-960, PD127391, AM-1091

Size Price Availability Quantity
5mg USD 48  USD48 In stock
10mg USD 62  USD62 In stock
25mg USD 108  USD108 In stock
50mg USD 196  USD196 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 365.79
Formula C17H17ClFN3O3
CAS Number 105956-97-6
Purity >98.5%
Solubility DMSO 1.8 mg/mL
Storage at -20°C
References

[1] Michael T Sweeney, et al. Front Microbiol. In vitro activity and rodent efficacy of clinafloxacin for bovine and swine respiratory disease

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Keywords: Clinafloxacin, CI-960, PD127391, AM-1091 supplier, Antibiotic, inhibitors

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