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Ciproxifan

Cat. No. M2522
Ciproxifan Structure
Synonym:

FUB-359

Size Price Availability
10mg USD 150  USD150 Out of stock
50mg USD 570  USD570 Out of stock
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Quality Control & Documentation
Biological Activity

Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

Chemical Information
Molecular Weight 386.4
Formula C16H18N2O2.C4H4O4
CAS Number 184025-18-1
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Frdric Chauveau, et al. Procognitive impact of ciproxifan (a histaminergic H 3 receptor antagonist) on contextual memory retrieval after acute stress

[2] Abhijit S Nair. Ciproxifan in preventing inhalational anesthetic-induced neurotoxicity!

[3] Vasudevan Mani, et al. Ciproxifan improves cholinergic transmission, attenuates neuroinflammation and oxidative stress but does not reduce amyloid level in transgenic mice

[4] Cheng-Wei Lu, et al. Ciproxifan, a histamine H 3 receptor antagonist and inverse agonist, presynaptically inhibits glutamate release in rat hippocampus

[5] S Hagenow, et al. Ciproxifan, a histamine H 3 receptor antagonist, reversibly inhibits monoamine oxidase A and B

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