Free shipping on all orders over $ 500

Chymostatin

Cat. No. M9318
Chymostatin Structure
Size Price Availability Quantity
1mg USD 95  USD95 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Chymostatin is a potent inhibitor of human leucocyte chymotrypsin-like protease. Its affinity to the leucocyte protease was found to be much higher than its affinity to bovine pancreatic alpha-chymotrypsin.

Chemical Information
Molecular Weight 607.7
Formula C31H41N7O6
CAS Number 9076-44-2
Form Solid
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Norbert E Juettner, et al. Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway

[2] Miaojuan Qiu, et al. Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells

[3] Chen Yang, et al. Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice

[4] Aftab Ahamed, et al. Chymostatin can combine with pepstatin to eliminate extracellular protease activity in cultures of Aspergillus niger NRRL-3

[5] P Libby, et al. Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle

Related Cathepsin Products
Z-Gly-Pro-Arg-AMC hydrochloride

Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate.

N-CBZ-Phe-Arg-AMC

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes.

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay.

(S, S)-Z-FA-FMK

(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor.

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen.

  Catalog
Abmole Inhibitor Catalog




Keywords: Chymostatin supplier, Cathepsin, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.