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Cholic acid

Cat. No. M9192
Cholic acid Structure
Size Price Availability Quantity
100mg USD 50 In stock
1g USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

Protocol
Cell Experiment
Cell lines HepG2 cells
Preparation method HepG2 cells are pretreated with the inhibitors NaN3 (1 mg/mL), Genistein (50 μg/mL), MβCD (10 mM), Nystatin (50 μg/mL), Chlorpromazine (10 μg/mL), and Cholic acid (1 mg/mL) for 30 min. After removing the inhibitors, the cells are incubated with CA-LPs for 2 h, and the cellular uptake of LPs is determined in the "In vitro cellular uptake assays" section.
Concentrations 1 mg/mL
Incubation time 30 min
Animal Experiment
Animal models Tg-CYP2D6 mice
Formulation 1% (w/w) Cholic acid-supplemented
Dosages 14 days
Administration fed
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 408.57
Formula C24H40O5
CAS Number 81-25-4
Purity >98%
Solubility DMSO: ≥ 40 mg/mL
Storage 4°C, dry, sealed
References

Mechanism of hepatic targeting via oral administration of DSPE-PEG-cholic acid-modified nanoliposomes.
Li Y, et al. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. PMID: 28280334.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cholic acid supplier, inhibitors

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