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Chlorpyrifos

Cat. No. M14545
Chlorpyrifos Structure
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Biological Activity

Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

Chemical Information
Molecular Weight 350.59
CAS Number 2921-88-2
Solubility (25°C) DMSO 50 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Behzad Mesbahzadeh, et al. Chlorpyrifos with Age-Dependent Effects in Cardiac Tissue of Male Rats

[2] Peng Yin, et al. Residue pattern of chlorpyrifos and its metabolite in tea from cultivation to consumption

[3] Xiao Huang, et al. Ecotoxicity of chlorpyrifos to aquatic organisms: A review

[4] Tahereh Farkhondeh, et al. Impact of chlorpyrifos on blood glucose concentration in an animal model: a systematic review and meta-analysis

[5] M G Barron, et al. Ecotoxicology of chlorpyrifos

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Keywords: Chlorpyrifos supplier, AChR/AChE, inhibitors, activators


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