Chlorphenoxamine is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent.
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Molecular Weight | 303.83 |
Formula | C18H22ClNO |
CAS Number | 77-38-3 |
Purity | >98% |
Solubility | 48 mg/mL in DMSO |
Storage | at -20°C |
Isolation of chlorphenoxamine metabolites in human urine and their identification.
Goenechea S, et al. Arzneimittelforschung. 1987 Jul;37(7):854-9. PMID: 3675683.
Related Histamine Receptor Products |
---|
Meta-Fexofenadine
Fexofenadine is a nonsedating antihistamine drug which is indicated for treatment of seasonal allergic rhinitis. |
Roxatidine Acetate HCl
Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation. |
Ranitidine HCl
Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers. |
Mizolastine
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. |
Loratadine
Loratadine is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.