Chlorphenoxamine is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||48 mg/mL in DMSO|
Isolation of chlorphenoxamine metabolites in human urine and their identification.
Goenechea S, et al. Arzneimittelforschung. 1987 Jul;37(7):854-9. PMID: 3675683.
|Related Histamine Receptor Products|
S 38093 is an inverse agonist at histamine H3 receptors, displays a moderate affinity for rat, mouse and human H3 receptors with Ki of 8.8, 1.44 and 1.2µM, respectively.
Emedastine Difumarate is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity.
Fexofenadine is a nonsedating antihistamine drug which is indicated for treatment of seasonal allergic rhinitis.
|Roxatidine Acetate HCl
Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.
Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.
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