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Chlorogenic acid

Cat. No. M3977
Chlorogenic acid Structure
Synonym:

NSC-407296,CQAs

Size Price Availability Quantity
500mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Chlorogenic acid inhibited the proliferation of A549 human cancer cells in vitro.Chlorogenic acid suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ cells in a dose-dependent manner.Chlorogenic acid also increased the enzymatic activities of glutathione S-transferases (GST) and NAD(P)H: quinone oxidoreductase. Further studies indicated that chlorogenic acid could stimulate the nuclear translocation of Nrf2 (NF-E2-related factor) as well as subsequent induction of GSTA1 antioxidant response element (ARE)-mediated GST activity.Chlorogenic acid inhibits Bcr-Abl (the fusion protein of Bcr and c-Abl) tyrosine kinase and triggers MAP kinases p38-dependent apoptosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 354.31
Formula C16H18O9
CAS Number 327-97-9
Purity >99%
Solubility DMSO
Storage at -20°C
References

Chlorogenic Acid stability in pressurized liquid extraction conditions.
Wianowska D, et al. J AOAC Int. 2015 Mar;98(2):415-21. PMID: 25905748.

Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid.
dos Santos MD, et al. Biol Pharm Bull. 2006 Nov;29(11):2236-40. PMID: 17077520.

Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols.
Lee WJ, et al. Carcinogenesis. 2006 Feb;27(2):269-77. PMID: 16081510.

Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid.
Feng R, et al. J Biol Chem. 2005 Jul 29;280(30):27888-95. PMID: 15944151.

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Keywords: Chlorogenic acid, NSC-407296,CQAs supplier, HIF, inhibitors

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