Chitosan is a natural polycationic linear polysaccharide derived from chitin.
Carbohydr Polym. 2022 Feb 15;278:118999.
Analysis of clinical trials on biomaterial and therapeutic applications of chitosan: A review
Chitosan purchased from AbMole
Molecular Weight | 161.16 |
Formula | (C6H11NO4)n |
CAS Number | 9012-76-4 |
Solubility (25°C) | Soluble in dilute aqueous acid (pH <6.5) |
Storage | 18-25°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Shijie Gabriel Kou, et al. Chitosan: A review of sources and preparation methods
[2] Federico Lopez-Moya, et al. Molecular Mechanisms of Chitosan Interactions with Fungi and Plants
[3] Zahra Shariatinia. Carboxymethyl chitosan: Properties and biomedical applications
[4] A Muxika, et al. Chitosan as a bioactive polymer: Processing, properties and applications
[5] V Patrulea, et al. Chitosan as a starting material for wound healing applications
Related Cell Transfection Products |
---|
Chitosan (MW 150000)
Chitosan (MW 150000) is a polycationic linear polysaccharide derived from chitin with a molecular weight of 150000.Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and anti-oxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
Chitosan (MW 30000)
Chitosan (MW 30000) is a polycationic linear polysaccharide derived from chitin with a molecular weight of 30,000.Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and antioxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
DMTAP
DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs. |
Polyethylenimine, Linear (MW 25000)
Polyethylenimine Linear (PEI) solution consists of a cationic polymer transfection reagent with a molecular weight of 25,000, which forms a complex with nucleic acids and allows the complex to enter mammalian cells. In addition, Polyethylenimine Linear is one of the most commonly used reagents in small to large scale transfection. |
Polyethylenimine, Linear (MW 25000, liquid)
Polyethylenimine Linear (PEI) solution consists of a cationic polymer transfection reagent with a molecular weight of 25,000, which forms a complex with nucleic acids and allows the complex to enter mammalian cells. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.