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CHIR-98014

Cat. No. M2305
CHIR-98014 Structure
Size Price Availability Quantity
10mg USD 220 In stock
50mg USD 680 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

CHIR-98014 is a potent and selective human GSK-3 inhibitor for human GSK-3ɑ and human GSK-3β with IC50 of 0.65 and 0.58 nM, respectively. CHIR-98014 inhibits human GSK-3β with Ki values of 0.87 nM. Although CHIR-98014 serves as a simple competitive inhibitor of ATP binding, CHIR-98014 exhibits from 500-fold to <1000-fold selectivity for GSK-3 versus 20 other protein kinases including CDC2, erk2, tie2, KDR et al. CHIR-98014 prevents CDC2 with an IC50 of 3.7 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 486.31
Formula C20H17Cl2N9O2
CAS Number 252935-94-7
Purity >99%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CHIR-98014 supplier, GSK-3, inhibitors

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