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Chelerythrine Chloride

Cat. No. M5319
Chelerythrine Chloride Structure
Size Price Availability Quantity
20mg USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

Chelerythrine has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis.

Chemical Information
Molecular Weight 383.82
Formula C21H18ClNO4
CAS Number 3895-92-9
Solubility (25°C) ≥ 3.9 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vieira SM, et al. Arch Biochem Biophys. Chelerythrine inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase and results in cell Ca(2+) imbalance.

[2] Bai LP, et al. Sci Rep. Recognition of chelerythrine to human telomeric DNA and RNA G-quadruplexes.

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Keywords: Chelerythrine Chloride supplier, PKC, inhibitors, activators


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