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Chelerythrine Chloride

Cat. No. M5319
Chelerythrine Chloride Structure
Size Price Availability Quantity
20mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Chelerythrine has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 383.82
Formula C21H18ClNO4
CAS Number 3895-92-9
Purity >99%
Solubility ≥ 3.9 mg/mL in DMSO
Storage at -20°C
References

Chelerythrine inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase and results in cell Ca(2+) imbalance.
Vieira SM, et al. Arch Biochem Biophys. 2015 Mar 15;570:58-65. PMID: 25721495.

Recognition of chelerythrine to human telomeric DNA and RNA G-quadruplexes.
Bai LP, et al. Sci Rep. 2014 Oct 24;4:6767. PMID: 25341562.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Chelerythrine Chloride supplier, PKC, inhibitors

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