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CGP 57380

Cat. No. M2506
CGP 57380 Structure
Size Price Availability
5mg USD 80 Out of stock
10mg USD 120 Out of stock
50mg USD 400 Out of stock
100mg USD 700 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CGP 57380 is potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 244.23
Formula C11H9FN6
CAS Number 522629-08-9
Purity >98%
Solubility DMSO 30 mg/mL
Storage at -20°C
  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CGP 57380 supplier, MNK, inhibitors

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