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CGI1746

Cat. No. M3620
CGI1746 Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 380 In stock
10mg USD 280 In stock
50mg USD 840 In stock
100mg USD 1200 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CGI1746 has exquisite selectivity for Btk and inhibits both auto- and transphosphorylation steps necessary for enzyme activation. CGI1746 blocks B cell receptor-dependent B cell proliferation and in prophylactic regimens reduces autoantibody levels in collagen-induced arthritis. CGI1746 decreases cytokine levels within joints and ameliorates disease. CGI1746 shows comparable efficacy to TNFα blockade and significantly reduces clinical scores, as well as joint inflammation, in mice or rats with established arthritis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 579.69
Formula C34H37N5O4
CAS Number 910232-84-7
Purity >98%
Solubility DMSO
Storage at -20°C
References

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.
Di Paolo JA, et al. Nat Chem Biol. 2011 Jan;7(1):41-50. PMID: 21113169.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CGI1746 supplier, BTK, inhibitors

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