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Cetirizine Di

Cat. No. M5506
Cetirizine Di Structure
Size Price Availability Quantity
100mg USD 65 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 461.81
Formula C21H27Cl3N2O3
CAS Number 83881-52-1
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
References

Effect of cetirizine on symptom severity and quality of life in perennial allergic rhinitis.
Skoner DP, et al. Allergy Asthma Proc. 2014 Jul-Aug;35(4):338-45. PMID: 24992553.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cetirizine Di supplier, Histamine Receptor, inhibitors

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