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CEP-37440

Cat. No. M4984
CEP-37440 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 108  USD108 In stock
2mg USD 50  USD50 In stock
5mg USD 85  USD85 In stock
10mg USD 148  USD148 In stock
50mg USD 580  USD580 In stock
100mg USD 980  USD980 In stock
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Quality Control & Documentation
Biological Activity

Preparation of fused bicyclic 2,4-diaminopyrimidine derivatives as a dual ALK and FAK inhibitor.

Chemical Information
Molecular Weight 580.12
Formula C30H38ClN7O3
CAS Number 1391712-60-9
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiao-Jing Pang, et al. Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy

[2] Gregory R Ott, et al. Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

[3] Israa Salem, et al. The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

[4] Ivana Sullivan, et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments

[5] Chaitanya Iragavarapu, et al. Novel ALK inhibitors in clinical use and development

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  Catalog
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Keywords: CEP-37440 supplier, ALK, inhibitors, activators


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