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CEP-37440

Cat. No. M4984

CEP-37440 Structure
Size Price Availability Quantity
2mg USD 110 In stock
5mg USD 160 In stock
10mg USD 240 In stock
50mg USD 650 In stock
100mg USD 950 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Preparation of fused bicyclic 2,4-diaminopyrimidine derivatives as a dual ALK and FAK inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 580.12
Formula C30H38ClN7O3
CAS Number 1391712-60-9
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CEP-37440 supplier, ALK, inhibitors

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