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Cefoxitin

Cat. No. M19921
Cefoxitin Structure
Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 75  USD75 In stock
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Quality Control & Documentation
Biological Activity

Cefoxitin is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.

Chemical Information
Molecular Weight 427.45
Formula C16H17N3O7S2
CAS Number 35607-66-0
Solubility (25°C) DMSO 85 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zaccaria Ricci, et al. Pediatr Infect Dis J. Population Pharmacokinetics of Cefoxitin Administered for Pediatric Cardiac Surgery Prophylaxis

[2] Zaccaria Ricci, et al. Pediatr Infect Dis J. Cefoxitin Prophylaxis During Pediatric Cardiac Surgery: Retrospective Exploration of Postoperative Trough Levels

[3] C V Sanders, et al. Ann Intern Med. Cefamandole and cefoxitin

[4] E O Stapley, et al. Rev Infect Dis. Cefoxitin and cephamycins: microbiological studies

[5] H C Neu. Rev Infect Dis. Cefoxitin: an overview of clinical studies in the United States

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