Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. Cefazolin has a strong effect on Gram-positive bacteria such as Staphylococcus aureus, hemolytic streptococcus, pneumococcus, diphtheria and Clostridium. Cefazolin has a strong effect on Gram-negative bacteria, especially for Klebsiella pneumoniae. Cefazolin is also effective against Escherichia coli, Proteus mirabilis and Salmonella typhi.
| Molecular Weight | 454.51 |
| Formula | C14H14N8O4S3 |
| CAS Number | 25953-19-9 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] K S Scher, et al. Am J Surg. Duration of antibiotic prophylaxis. An experimental study
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