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Cearoin

Cat. No. M11037
Cearoin  Structure
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Biological Activity

Cearoin enhances autophagy and induces apoptosis by promoting ROS production and activating ERK.

Chemical Information
Molecular Weight 244.24
Formula C14H12O4
CAS Number 52811-37-7
Solubility (25°C) N/A
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tonking Bastola, et al. Molecules. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells

[2] Megumi Funakoshi-Tago, et al. Int Immunopharmacol. Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway

[3] Megumi Funakoshi-Tago, et al. Int Immunopharmacol. Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway

[4] Padam Kumar, et al. Bioorg Med Chem Lett. Neoflavonoids as potential osteogenic agents from Dalbergia sissoo heartwood

[5] S C Chan, et al. Planta Med. Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera

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