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CC-885

Cat. No. M14863
CC-885 Structure
Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 170  USD170 In stock
25mg USD 385  USD385 In stock
50mg USD 570  USD570 In stock
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Quality Control & Documentation
Biological Activity

CC-885 is a regulator of CRBN protein with a wide range of strong CRBN-dependent anti-proliferative activity in various tumor cell lines, with enhanced anti-proliferative activity compared to lenalidomide and pomalidomide.CC-885 promotes the binding of CRBN to the novel substrate GSPT1, targeting its degradation.

Chemical Information
Molecular Weight 440.88
CAS Number 1010100-07-8
Solubility (25°C) DMSO 67.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alireza Baradaran-Heravi, et al. Effect of small molecule eRF3 degraders on premature termination codon readthrough

[2] Min Zhao, et al. Cereblon modulator CC-885 induces CRBN-dependent ubiquitination and degradation of CDK4 in multiple myeloma

[3] Lifeng Li, et al. A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer

[4] Bing-Bing Hao, et al. The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L

[5] Mary E Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

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  Catalog
Abmole Inhibitor Catalog




Keywords: CC-885 supplier, Ligand for E3 Ligase, inhibitors, activators


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