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Cassiaside C

Cat. No. M10618
Cassiaside C Structure
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5mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Cassiaside C (Toralactone 9-O-β-D-gentiobioside) is a naphthopyrone isolated from the seed of Cassia tora and has inhibitory activity on advanced glycation end products (AGE) formation in vitro.

Chemical Information
Molecular Weight 596.53
Formula C27H32O15
CAS Number 119170-52-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ye Jin Kim, et al. Int J Mol Sci. Cassiaside C Inhibits M1 Polarization of Macrophages by Downregulating Glycolysis

[2] Md Yousof Ali, et al. Molecules. Phytochemistry, Ethnopharmacological Uses, Biological Activities, and Therapeutic Applications of Cassia obtusifolia L.: A Comprehensive Review

[3] Lu Wang, et al. Zhongguo Zhong Yao Za Zhi. [UPLC-MS~n analysis and certification evaluation of main chemical composition in naphthopyrone reference extract of Cassiae Semen]

[4] De-Yong Zhou, et al. Zhongguo Zhong Yao Za Zhi. [Study on naphthopyrone reference extract and application on assay of Semen Cassiae]

[5] Zhaojun Zhang, et al. J Org Chem. Total synthesis of the antiallergic naphtho-alpha-pyrone tetraglucoside, cassiaside C(2), isolated from cassia seeds

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