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Carmofur

Cat. No. M2247
Carmofur Structure
Synonym:

HCFU

Size Price Availability Quantity
200mg USD 120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Carmofur is a pyrimidine analogue used as an antineoplastic agent. Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. As fluorouracil, carmofur has been known to induce leukoencephalopathy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 257.26
Formula C11H16FN3O3
CAS Number 61422-45-5
Purity >98%
Solubility DMSO 40 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Carmofur, HCFU supplier, DNA/RNA Synthesis, inhibitors

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