Free shipping on all orders over $ 500

Carboxytolbutamide

Cat. No. M8841
Carboxytolbutamide Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

In vivo tolbutamide metabolite. Major urinary metabolite of tolbutamide.

Chemical Information
Molecular Weight 300.33
Formula C12H16N2O5S
CAS Number 2224-10-4
Solubility (25°C) methanol: soluble
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shotaro Uehara, et al. Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes

[2] Shaoyu Zhang, et al. Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats

[3] E NELSON, et al. Kinetics of carboxytolbutamide excretion following tolbutamide and carboxytolbutamide administration

[4] G Raghow, et al. High-performance liquid chromatographic assay of tolbutamide and carboxytolbutamide in human plasma

[5] D L Vesely. The comparative effects of tolbutamide and the non-hypoglycemic analog carboxytolbutamide on guanylate cyclase activity

Related Products
Linderene acetate

Linderene acetate is a prolyl endopeptidase inhibitor, which can be isolated from the root of Lindera strychnifolia.

Pralmorelin

Pralmorelin (also known as KP-102, GPA-748, GHRP-2, and Growth Hormone Releasing Peptide-2) is a potent growth hormone secretagogue that acts on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone release. It acts as signal molecules that are involved in the control of cell growth and differentiation.

Methylarbutin

Methylarbutin (ß-PMP-Glc;4-Methoxyphenyl β-D-Glucopyranoside) is an ice recrystallization inhibitor (IRI).

SLK/STK10-IN-1

SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.

PP405

PP405 is a potent localized mitochondrial pyruvate carrier (MPC) inhibitor that acts on cellular metabolic pathways to up-regulate LDH and activate stem cells to promote hair growth, and can be used in studies related to androgenetic alopecia.

  Catalog
Abmole Inhibitor Catalog




Keywords: Carboxytolbutamide supplier, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.