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Carbetocin

Cat. No. M9193
Carbetocin Structure
Size Price Availability Quantity
10mg USD 90 In stock
50mg USD 350 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Carbetocin is an agonist at peripheral oxytocin receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 988.16
Formula C45H69N11O12S
CAS Number 37025-55-1
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth.
Widmer M, et al. N Engl J Med. 2018 Aug 23;379(8):743-752. PMID: 29949473.

Development and stability of a heat-stable formulation of carbetocin for the prevention of postpartum haemorrhage for use in low and middle-income countries.
Malm M, et al. J Pept Sci. 2018 Jun;24(6):e3082. PMID: 29700898.

Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: a randomised trial.
Moertl MG, et al. BJOG. 2011 Oct;118(11):1349-56. PMID: 21668768.

Related Oxytocin Receptor Products
Oxytocin (Syntocinon)

Oxytocin (α-Hypophamine) is a mammalian neurohypophysial hormone; its actions are mediated by specific, high-affinity oxytocin receptors; ligand of oxytocin receptor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Carbetocin supplier, Oxytocin Receptor, inhibitors

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