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Captisol(SBE-β-CD)

Cat. No. M4837
Captisol(SBE-β-CD) Structure
Synonym:

SBE-β-CD;Sulfobutylether-β-Cyclodextrin

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
1g USD 80 In stock
5g USD 180 In stock
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Quality Control
Biological Activity

Captisol is a unique reproducible mixture of polyanionic β-cyclodextrin derivatives in which a sodium sulfonate salt is tethered to the lipophilic cyclodextrin cavity by a butyl ether group, or sulfobutylether (SBE). The sulfobutyl ether (SBE) substituent is introduced at the 2, 3, and 6 positions in one or more of the glucopyranose units in the cyclodextrin structure. 

Product Citations
Customer Product Validations & Biological Datas
Source J Biomed Mater Res B Appl Biomater (2016). Figure 3. Captisol
Method Transmission electron microscopy
Cell Lines MRC-5 cells
Concentrations 1 μM
Incubation Time 24 h
Results Deionized water-dispersed ICG, SCyD, and MCyD showed a size distribution ranging from 2 to 200 nm.
Source J Biomed Mater Res B Appl Biomater (2016). Figure 1. Captisol
Method Fluorescence
Cell Lines
Concentrations 10 mM
Incubation Time 24 h
Results Over 24 h, ICG retained just 0.383 of its initial fluorescence in water, while MCyD-I and SCyD-I in water retained 1.943 and 2.063 higher fluorescence than ICG at t0. In PBS, ICG retained 0.753 of its initial fluorescence while MCyD-I actually increased to 29.863 and SCyD-I retained 20.833 of initial ICG fluorescence in PBS.
Protocol
Cell Experiment
Cell lines Caco-2 cells
Preparation method The cells were then preincubated for 30 min without Nos solution+permeation enhancer CH or CP and then incubated for 120 min at 37 ℃ with the Nos solution (50 mg/ml)+permeation enhancer CH or CP.
Concentrations 50 mg/ml
Incubation time 2 h
Animal Experiment
Animal models pig
Formulation 10-mL solution composed of 25% water and 75% PEG400
Dosages 5 mg/kg
Administration bolus infusions
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1451.29
Formula C50H84Na2O41S2
CAS Number 182410-00-0
Purity 99.08%
Solubility Water > 100 mg/ml
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Captisol(SBE-β-CD), SBE-β-CD;Sulfobutylether-β-Cyclodextrin supplier, inhibitors

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